Topic

Disease

What goes wrong, and what a society decides to do about it.

8: in history
13:00: average
104 min: in total
109: across the network

Disease across the network →

All briefs8

13:00

Christopher Columbus

1451–1506

Christopher Columbus, a Genoese sailor working for the Spanish crown, crossed the Atlantic four times between 1492 and 1504, reaching the Bahamas, Cuba, Hispaniola and later the South and Central American coasts while insisting throughout that he had reached Asia. His governance of Spanish settlements involved documented brutality toward indigenous populations that led to his removal from office, and modern historians increasingly weigh his navigational achievement against the enslavement and demographic collapse that followed his voyages.

13:00

Marcus Aurelius

121–180

Adopted as heir in 138 and made emperor in 161, Marcus Aurelius spent much of his nineteen-year reign fighting wars in the east and along the Danube while a severe epidemic killed millions across the empire. His private notebook, the Meditations, records a Stoic-trained mind working through the burdens of rule, but the actual chronicle of his reign rests on other, less personal sources whose own reliability historians still weigh carefully.

13:00

Sigmund Freud

1856–1939

From The Interpretation of Dreams in 1899 through decades of case studies and theoretical works, Sigmund Freud built psychoanalysis into an international movement centred on the unconscious, infantile sexuality and the talking cure. His methodology, including the abandoned seduction theory and the botched treatment of patient Emma Eckstein, has drawn sustained criticism, and his scientific status remains genuinely contested nearly a century after his death in 1939.

13:00

Black Death

1346–1352

The Black Death reached Europe through Crimea in 1347 and, over the following six years, killed an estimated quarter to three-fifths of the continent's population, though contemporary records kept no census and modern historians' own population baselines vary enough to make precise mortality figures unreliable. Even the mechanism of its spread, long assumed to run mainly through rat fleas, is now disputed by researchers who argue human fleas and lice, or straightforward person-to-person transmission, better explain how fast it moved through cooler parts of Europe.

13:00

Second plague pandemic

1340–1880

The second plague pandemic began with the Black Death, which reached Europe in 1346 and is estimated to have killed between 75 and 200 million people across Eurasia within a few years, before the disease became endemic and returned in recurring outbreaks including the Great Plague of London in 1665 and 1666 and a final wave in Ottoman territory as late as 1813 and 1814. Historians reconstruct its spread from parish and tax records, contemporary accounts such as Boccaccio's Decameron, and, more recently, DNA extracted from victims' teeth, evidence that has confirmed Yersinia pestis as the cause while leaving the pandemic's precise geographic origin and eventual decline still not fully explained.

13:00

Spanish conquest of the Aztec Empire

1519–1521

Hernan Cortes landed on the Gulf coast of Mexico in 1519 and, through alliances with Aztec tributary peoples resentful of imperial rule, marched on Tenochtitlan, where an initial peaceful reception collapsed into violence, a chaotic Spanish retreat, and a devastating smallpox epidemic before the capital finally fell after siege in August 1521. Spanish accounts dominate the surviving record, though indigenous testimony recorded after the conquest under colonial supervision offers a partial counterweight. Historians now doubt several staples of the traditional story, including the belief that Moctezuma saw Cortes as a returning god, tracing that idea only to European writing from the 1540s.

13:00

Spanish conquest of the Inca Empire

1532–1572

A smallpox epidemic killed the Inca emperor Huayna Capac around 1525 and triggered a civil war between his sons that was still raging when Francisco Pizarro landed with roughly a hundred and eighty men in 1532. Pizarro ambushed and captured the victorious Atahualpa at Cajamarca, collected an enormous ransom, then executed him anyway, and organised Inca resistance continued in diminishing form until 1572. Most surviving accounts derive from Spanish chroniclers, and historians still dispute how much credit for the conquest belongs to Spanish technology versus the empire's prior weakness, while disease ultimately killed far more people than any battle did.

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Panama Canal

1881–1914

Ferdinand de Lesseps's French company began excavating a sea-level canal across Panama in 1881, a project that collapsed in bankruptcy in 1889 after roughly 22,000 deaths from disease and an underestimation of the terrain's difficulty. The United States acquired the French assets, engineered Panama's 1903 secession from Colombia to secure treaty rights, and completed a lock-and-lake canal in 1914 after further improving disease control, before transferring full sovereignty to Panama in 1999.